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Keywords 0 25 BACKGROUND AND AIMS In ancient Middle Eastern cultures, the liver was believed to be the site of life itself, just as the heart was so considered in the Western society of the time [1]

However, Dox-induced expression of RRM1 and RRM2 alone was not sufficient to revert this protective effect, possibly because of coordinate down-regulation of multiple nucleotide metabolic pathway genes in response to p53 stabilization (Fig 3B)

Neurons were held at 60 mV in current clamp mode, and ramps of depolarizing current (1-s duration, peak amplitudes of 100, 300, 500 and 700 pA) were injected into each neuron

Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)

The animals were intraperitoneally treated with different doses of acetyl-L-carnitine (30, 60, and 100) for 6 days